Acid Pump Medical Definition - A Proton Pump

Acid pump, also known as a proton pump, refers to a class of molecules that are responsible for moving protons, or positively charged ions, across cell membranes. These pumps are particularly important in the digestive system, where they help to regulate the levels of acidity in the stomach.

Proton pumps are typically found in the parietal cells of the stomach lining, where they are responsible for producing the hydrochloric acid that helps to break down food as it passes through the digestive system. These pumps work by using energy to move positively charged hydrogen ions from the cytoplasm of the cell out into the lumen of the stomach, where they combine with chloride ions to form hydrochloric acid.

Proton pumps are also found in other parts of the body, including the kidney, where they regulate the levels of acid and electrolytes in the blood, and in the osteoclasts of the bone, where they help to break down bone tissue.

The role of proton pumps in the body makes them an important target for medication. Proton pump inhibitors, or PPIs, are a class of drugs that are used to treat a range of digestive disorders, including acid reflux, gastroesophageal reflux disease (GERD), and peptic ulcer disease.

PPIs work by blocking the action of the proton pumps in the stomach lining, which reduces the amount of acid that is produced in response to food. By decreasing the acidity of the stomach, PPIs can help to alleviate the symptoms of acid reflux and related conditions.

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